A: Yes. Although it doesn’t say it, the function of the card requires that you set your main hand aside, so that you can be sure you are playing the exact five cards you drew for the Mission, and not other cards from your “main” hand. Also, just as with Draw 3 Play 2 of Them, or Draw 2 & Use ‘Em, anything you play as part of the Mission which references “your hand” applies to your main set-aside hand, and not the temporary hand of cards you’re playing from.