Q: To win with the Goal I’ll Hold ‘Em Off! does the Weapons Bonus Rule have to be in effect?

A: No. (It would need to say so on the Goal card for that to be the case.) POW! Keepers “can” be used as weapons, when the circumstances are right, i.e. when the Weapon Bonus is in play, OR when the Goal is “I’ll Hold ’em Off!”