Suppose my opponent has the Zombie Quartet, I have the Shotgun and a Single, Duo, and Trio Zombie, and the goal is “4,3,2,1.” I have not drawn yet. May I shoot the Zombie Quartet with the Shotgun before I draw, so that I can take it myself?

A: Yes. You can use the optional Shotgun action at any point during your turn, including as the very first thing you do before drawing cards.

(You could use the Laser Pistol in Star Fluxx to shoot the Cute Fuzzy Alien if it had a Creeper attached, to put it on top of the draw pile, too)