Q: If I have The MacGuffin, and my opponent has another Object in play, but no cards left, who wins? Is it a tie?

A: Note #4 in the Turn Options section. If someone’s turn comes around, and they have no cards in hand, but they have an Object in play, then they must take the turn option of discarding the Object. Ties can happen in Get the MacGuffin, but not in this way.