A: No. If you have played Let’s Simplify, you must discard all of the Rules of your choosing before you can take any optional Free Actions, like using Crime Happens. That said, there’s no reason you have to discard Crime Happens. You could decide to discard Arkham Asylum, thus releasing the Villains to the players. And that’s it. You could decide you’re done Simplifying. Then, having a Creeper, you could use Crime Happens to take a Keeper from one of the other players.

But you CAN’T decide to trash Arkham Asylum, get a Creeper, use the Free Action allowed by Crime Happens, and then finish Simplifying by trashing Crime Happens. The stuff that happens as a result of playing Let’s Simplify is considered to be simultaneous. All Rules discarded go *poof* at the same time. You can’t insert any other game actions in the middle of that happening.