…For example, if the first New Rule that comes up is a Hand Limit 1, and the next one that comes up is a Hand Limit 3, does everyone have to comply with the Hand Limit 1, or can they wait until all the New Rules have been played, resulting in a final state of Hand Limit 3?

…Or, if the first New Rule that comes up increases the Draw, and the next one decreases it, should the active player Draw up to the requirement for the first rule, or wait until all the New Rules have come out and only Draw up to the number required by the later New Rule?

A: You should fully comply with each New Rule as it comes up. So, in the Hand Limit example, everyone (except the active player) needs to discard down to 1 card in hand (and will probably be irked when it goes back up again). The active player, of course, doesn’t have to comply with Limits until their turn ends. In the increased Draw rule example, the active player should Draw up to the higher number, and then draw no more when it goes down again.